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These served as simple environmental cues for drug use. Next, some rodents were given a form of HDAC5 that traveled straight to the nuclei of neurons. Those rodents still pressed the lever just as many times to receive drug, Adult seeking hot sex Mavisdale Virginia 24627 that HDAC5, on its own, was likely not blocking genes that promoted early drug-seeking behavior.

Yet the next experiment proved that HDAC5 reduced drug-seeking behavior during abstinence. To simulate withdrawal and abstinence, rodents were given rest without cocaine for one week, followed by a period during which they had access to the lever again. To simulate relapse, the rodents were shown the environmental cues again, this time Adult seeking hot sex Mavisdale Virginia 24627 having pressed the lever.

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Taniguchi et al. The authors further show that HDAC5 negatively regulates Npas4 expression and that both drug and environmental cues produce a rapid and transient increase in Npas4 expression Adult seeking hot sex Mavisdale Virginia 24627 a small subpopulation of cFos-positive Nac neurons. Finally, the authors show that Npas4 contributes to learning and memory processes associated with cocaine reward.

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